Am I right to think this will create a cycle of steadily escalating damage?
A 10/5 PD Bloodletter, a Snowshoe or Red Card with the on break amp damage anoint, a Knife Drain Launchpad, and your favorite rocket launcher (preferably something with unlisted projectiles, like the Plaguebearer).
Do a slam, which breaks then heals your shield, then fire an amped shot. Between PD, the amped shot and Groundbreaker, the damage dealt by your slam and amped shot should increase with each cycle until you run out of mobs. You should be able to push that even further with the 160 splash anoint, since it increases both damage and shields.