I’m sure this goes along the same lines for every melee character, but I just came out of a 20 or so minute “Boss Battle” with Isic’s floating head. It comes down to me basically pouncing to the ground and wildly swinging until he hopefully comes into melee range. Also the shockwaves don’t really do much either when you’re flying around.
I haven’t tried 1v1ing Isic with any other melee characters but Damn this seems super stacked against you.