So, assuming that the story told to Loader Bot is reliable (and for the most part I think it is) and that Tales from the Borderlands is canon let’s talk about the implications that is has for Borderlands 3.
These are the main 3 I can come up with:
Scooter is dead, I guess Janey Springs will take over for him?
Fiona could be a playable vault hunter. Seems possible to me. I doubt Rhys will be playable. I don’t think he fired a gun the entire game.
Atlas is back as Rhys is CEO now. ATLAS HYPE
Also I hope that they at least reference Rhys, Vaughn, Sasha, Fiona, etc. I’m pretty sure that they will at least make them minor characters in BL3.

Interestingly enough, maybe that Jack wouldn’t be as evil because he wouldn’t have experienced anything else from the rest of the PreSequel. He could certainly be different anyhow 