Oh. I forgot…
For killing X number of enemies, don’t destroy the anchors that spawn them.
Never had a problem with not enough enemies unless I destroyed what spawned them or activated a trigger that canceled reinforcements. But the challenges always trigger in the same spots, if you know where they trigger, just be prepared. Like I do with the swarmers in the void mission.
And I know you can get shards and other drops from kills, but its unreliable and takes too long to be worth mentioning
Not killing the anchors is counter-intuitive though, like saying if you want to get gold, DON’T rescue the data bots. (likewise for swarmers). Also, drops specifically is faster from killing enemies, especially in locations where there isn’t all that many chests/shards (like the bridge at the Renegade). And shards are sometimes easier to get the last few from enemies, especially in places where the shard boxes are placed out of range (like the 2nd defense area in Sabotage)
I don’t know about the medals and overall score. I got gold the first time on each mission, I always get the highest score on my team 
. (Due in part to me taking all the chests/drops my teammates ignore)
Im just giving advice for completing the challenges.
2nd defense on sabotage, I know what 2 chard boxes your talking about lol. I never have a problem getting those since I only ever play Kleese on that mission since, atm its near impossible to beat without him (5-player)
I feel maybe I should somewhat retract my earlier mini-rant about double kills with Toby because I have realized something… the difficulty of the challenges even him out. I literally am in the middle of an advanced Algorithm run with him and have fully completed (0-100%) three of his lore challenges and I haven’t even fought Arachnis yet… hu.
Post is moved.
Just pointing out - I think the topic is about the ingame mission challenges that pop up during a PvE-mission, not about Lore challenges 
May I move your post to this topic? Seems to fit better
-> Toby's Lore, Killing on Rails, Double-Kill Core Discharge