I am trying to delete the subfolders in “HomeworldRM\Bin\Profiles”, but whenever I start the game, Steam re-downloads these folders. How can I delete them so that they stay deleted? Thanks.
Steam is re-downloading them from your steam cloud. You can try deleting the profiles from within Homeworld or you could disable steam cloud for Homeworld by accessing Homeworld’s properties > updates from within steam, then deleting the profile folders again.