Disk not reading

My problem is when my xbox hard drive is plugged into my xbox my borderlands 2 disk says it is unreadable therefore making it so i am unable to play, and once i remove the harddrive the game is perfectly fine. Any idea on how to fix my problem? ( I normally would be fine without using my harddrive but without it i am not able to play any of the DLC’s)

That is weird indeed. Do you have the room to install the game to your hard drive?

I have the game downloaded on my harddrive and even then it still says disk is unreadable