Given how Athena looks in the trailer, I'm guessing
that SOMETHING is corrupting the Vault Hunters slowly. It might not
affect all of them, (Claptrap or Zero may stay normal) but the
protagonists are going to be a lot of trouble if the Vault Hunters are
Look, from BL1, we have the most powerful siren on Pandora, a man who
can punch explosions with his bare hands without any damage, and a man
who single-handedly won the Underdome. From TPS, we’ve got an ex-Atlas
assassin who nearly took down an entire gun corporation by herself, an
annoying robot who is also a capable medic and can’t be destroyed, an
arrogant big game hunter who freezes whole armies if they touch her, and
probably a body double with wrist lasers, holograms and a lot of
bonuses to the weapons he uses. From BL2, there’s a glory hound with an
extremely overpowered turret, another Siren who can brainwash enemies
into fighting for her, a midget on Steroids who can dual wield rocket
launchers without suffering from recoil, an assassin who one-shots
people with a sniper rifle, pistol or katana, an 18-year-old engineering
genius with a floating death machine that wipes out bandit armies, and a
6 foot tall badass Psycho can can’t be put down.
They are all extremely dangerous and are shown to be capable of
looting stuff while wiping out whole regiments in 15 minutes or so, and
could pose a serious threat to the protagonists if they go after them.
Now, onto my next point. The Vault Key is an artifact on par with the One Ring of Sauron. For anyone who hasn’t read or watched The Lord Of The Rings,
the Ring corrupts people by giving them power yet twisting and breaking
them to obey the will of Sauron. Could the new Vault or the Vault Key
found from BL2 corrupt the Vault Hunters slowly? Lilith is seen being
very cold and ruthless in TPS…so it’s not long before the corruption
spreads to Brick and Mordy.
On the other hand, Jack said that he’s made sacrifices to bring order
to Pandora. Seeing how much of a ruthless dictator he is, that started a
3-year war that killed billions of people, I wouldn’t be surprised if
one of his more successful plans was to “put pheromones in the air that
make the Vault Hunters go nuts.”
The third option is that Jack’s AI Ghost can possess people somehow. That would be scary.
Or, Fiona and Sasha just really pissed Athena off or something.