I just started playing bl2 a couple months back, got to op4 right before the dlc came out and I’m op10 now with Maya. I have accumulated the best quest related gear pretty much along with numerous other, easier to get pieces of endgame gear. I would say I’m more of a casual but have bursts of intensity.
Honestly, I’m very good at gaming but far from the best and I’m chugging along. I beat tiny Tina’s story, new dlc including haderax, just beat muderlins 3+4 on op10, 3 was awful, probably took 13 or 14 attempts, finally had to switch to neoganater to stay alive long enough to kill things. Had to switch back to bee/hawk for 4 though, winded up failing twice without it.
These little tweaks are what will help you succeed, I switched weapons and relics numerous times on 4, depending on the enemies. I’ve also farmed the heck out of Uranus, midgets, tubbies, handsome sorcerer, and the top tier weapon quests so I have better versions of all the gear to switch between.
Relics and class mods you can use lower level ones, you just want the variety. I have all three blood of the ancients at various levels and same with legendary class mods, sheriff’s badge (level 50), explosive relic, top quality blue class mods.
I also use different specs too because some skills are just better suited to the gear or area you’re in. Snap a screen shot of your favorite specs or save it to your browser in the calculator.
TLDR: adapt, understanding your enemies as well as your characters strengths and gear will help tremendously. You still have to put time in to get great gear though. Took me about 1.5 hours to get a flying sandhawk of each element and it only took about 15 seconds to get a new roll. Even with those rolls, I have two that have weaker grips.