On XB1 will BL3 support Cross Reigon play?

I ask as I am in the US and I want to play with my friends over in the UK. If so does the langue settings need to be set to the UK or would I be able to add them and play with as is.

Unless I’m mistaken the language settings don’t matter for cross-region play. It should behave as all other games in the series and as long as you have them added you can join.