Pc Crashing when fighting

I started playing Borderlands 2 again and while fighting my monitor will randomly turn a random color and the sound will start to cut out until nothing entirely. Then my second monitor looses connection. I have to manually restart my pc by holding the power button.

My friend and i were farming the death race tier 3 and it was completely OK. But as soon as we left to go do a mission and started fighting guys i would crash.

Keep in mind its not as soon as we start fighting baddies but it happens after 5 min or 50 min, its random
I have already tried reinstalling my video drivers and reinstalling Borderlands.

I would appreciate all the help i could get.