I’ve rebound skill one and two to apostrophe ( ’ ) and period ( . ) to mesh with a dvorak keyboard layout. The key bindings work fine for using skills, but in the helix screen they aren’t respected and Q and E are still used to select the upgrade. This is particularly annoying because E is Strafe Right. It would be good if the upgrade select options mirrored the skill use buttons.
Similarly, but much less annoyingly, the keys for navigating the menus seemed to be fixed to things that make sense for a qwerty keyboard with no option to change them.