Red chests - bug or confusing expected behavior?

I cannot consistently get red chests to reset. For example, I have 2 characters who have completed the storyline through Athenas/Traunt. On character #1, the red chest from the brewery quest is farmable. On character #2, the chest chest is already open and empty on game reload. It was lootable one more time after progressing in the main story and is now open again. For both characters, the red chest from Ava’s quest is stuck open and empty.