So to be clear about loot

There is no reason to loot chest and boxes cause the weapons are set to the old mayhem 4 damage?
does this affect anything else in the same way?

Mission rewards, crew challenges, weapon vending machines and items from the lootsplosion modifier. Might be more but those are the ones I know of

loot tinks are not scaled as well

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ok and did they ever fix the lower mayhem mode version drops on mayhem ten?

I don’t think so, not sure on that though haven’t played much since m2.0 tbh