I just had an epiphany. I know who the real villain of the entire Borderlands franchise is. A psychotic, blood thirsty manipulator whose been operating in plain view this entire time, bribing, tricking, coercing, and seducing everyone who crossed her path to do her bidding. A corrupt warlord who would force every man, woman, and child on Pandora to fight to the death for her own amusement, and who has successfully turned friend against friend and hero against hero in the past, a character whose very name means insane determination; Mad Moxxi.
What was Moxxi when she was first introduced? A fight promoter who ran a death-match arena. And in BL2 her main motivation for stopping Jack is that he shut down her arena. She also says she dumped him, calling out his plastic surgery, and saying he was clearly too extreme and violent for her. But when we see her in Pre-Sequel their relationship is already a thing of the past, he hasn’t had surgery yet, and he’s actually pretty meek. Yet she is running a bar, meaning her arena was also a thing of the past. In short; MOXXI WAS LYING.
But there is more to it than personal revenge; in Torgue’s DLC for BL2 she forces Mister Torgue to sign over control of his arena to her because, as she admits, death match arenas ARE ILLEGAL. And what was Jack trying to do in BL2? Bring law and order to Pandora.
This entire time Moxxi was the true villain; deliberately keeping Pandora a lawless killing field just so she could make a profit off her arenas, and she specifically targeted, seduced, manipulated, and betrayed Jack, and later manipulated Lilith and Roland into trying to kill him, in order to prevent the rule of law coming to her home planet and destroying her business interests.