So, obviously there will be story spoilers in here. You’ve been warned.
My guess is that The Destroyer isn’t dead and Tyreen just absorbed a small portion of it’s power. We killed her. Not The Destroyer. How else would you explain a couple of schmucks with green tier guns killing a creature so devastatingly powerful that an incredibly advanced alien race who might have even created space-magic needed to sacrifice their entire civilization to simply seal it away because they couldn’t actually kill it.
Granted, this assumes a few things about the Eridians such as that they wanted to kill this creature, but couldn’t, but I mean, you don’t Parallax (aka: bury something deep down) instead of kill it if it can EAT STARS.
BL4 might be something akin to The Great Vault having been briefly opened allowing The Destroyer a means of attempting to release itself. I can see that leading to two possibilities:
The Vault Hunters/Crimson Raiders set out to find a way to kill/re-seal The Destroyer and find the last one/few living Eridians who have disappeared somewhere “off-the-grid” or even slipped into an alternate plane allowing them more time to research ways of effectively killing these monsters they sealed/something similar. We bring them back and we kill The Destroyer. Happy Happy Joy Joy.
The Destroyer starts unleashing hell on the universe and we need to find a way to re-seal it/kill it leading up to us (with the help of the Sirens) sacrificing our own civilization to re-seal/kill outright The Destroyer like the Eridians did before us. (kind of a “vicious cycle of sacrifice” thing).
I could be WAY off, but that’s just where my Writer’s mind goes with the story and evidence I have seen and been presented with. What about y’all? Any educated guesses where they’ll take the story next given they clearly have a sequel in mind? I’m asking about “logical next step” in the story, not necessarily what you WANT to happen.
(if you wanna say what you want to happen then that’s chill, just mark it as such. I’d personally LIKE to see a story where another all out corporate war breaks out and we’re mercenaries in the middle of the squabble).