What if the cutscenes and dialogues and ending scene changed the fate of pandora. Depending on the vault hunter you select? On bad side you fallow missions only to betray lilith ect. On good side you save them. And some side missions change depending on the charecter. For example good talks to tiny tina bad talks to atlas or psychos have you doing outrageous funny crazy missions.
Vault hunter ideas
A new kreig but with a chainsaw malee and gun damage with laser eye like the rats have.
An Angel clone with eridium powers for a siren
Ryse echo eye critical damage tree and hack makes robots become alleys.
Loaderbot exo with exoskeleton fast gunzerk type
A psycho that has a varkid for a skill
And explosive damage a crazy take damage give damage type. Just some ideas mad moxxi type would be cool