Update issues? Wont save and quit, no voices, broken fast travel

After the updating had finished, the game loaded fine, played fine for the first 2 minutes but then the characters/enemies all went silent. The guns still made noises, the action skill still makes noises but no-one speaks not even my own character (Zero). Even the subtitles have gone.
On top of this the fast travel no longer works, anywhere i try to go it just comes up with a black screen that says ‘loading’ and stays like that and the save and quit option no longer quits. It makes the motion of saving the game but leaves you there not returning to the main menu.

This only seems to be an issue with the one save file, my other character works fine, no issues. so i dont know if this is an update issue or just a corrupted save file.
Any ideas?