Doing a tandem Krieg and Sal where I level them up doing the same missions and end them on the same level, then swap the appropriate gear afterward. Today was all about farming the dust before doing all the Lynchwood missions in the optimal order (which changes for me once I have Mcnally unlocked):
I start with the Bane: Horace's Echo behind Ellie's in Bug Gulch
Farm Mobley & Getty
Walk off of the ledge by the second cemetary plot at Boot Hill Church yard & get a car
Jump the low peak to the Red Buzzard Nest's chest
Drop down in the car to Mcnally's shack
Drive through the Dahl Oil wells to check for the Gwen's Head if it's not at Ellie's en route to the Lynchwood train station
Kill the Zaffords, hope for a maggie, check for the Gwen's Head if needed
In Lynchwood get the bounties from the board
run down & get Dukino freed
En route to getting through town to the stairs to get to the medicine, check the bank
Get the Laxatives, then get the medicine
Go get the skag bites to feed dukino and head up and get Gar's Echo
Feed dukino the skag bites & head out to get skag tongues
Head up to blow up the train and get the Bomb From Mad Dog
Kill the three skags before the elevator and try and get crits so you have 3 of the five skag tongues needed.
Grab the bomb cart and put it in place.
Head up to Mad Dog's area and kill him en route to the detonator.
Blow up the Train and head towards the drilling area and Kill Skag Riders for the remainder of skag tongues if possible
Feed the little skag the laxative and pick up the mixture when it puke-dookies
Crit that little skag for another tongue if you need it.
Head over to the grave across the drill yard to get the Bane.
Head down to the bank & blow it up. Run out of town *turn in the skag tongues if you have enough on the way out of town)
Hide the Loot from the bank robbery, and if needed kill Posse members and crit their skags to get tongues
On the way back into town (double back the way you came at the end of the tracks) get dukino and escort him to the Mine to complete his mission set.
Go to the bounty board and turn in all the missions to unlock the shoot out with the sheriff.
Head to main street and kill Nisha the sheriff and leave Lynchwood... for now.
That run went pretty quickly for me.