I really fail to enjoy running around shooting bobble heads, especially when they clip through all models. Also being forced to change the core game play to be able to play MH10 just suck.
So far as Fl4k the least immersion breaking settings and modifiers I found is to run MH8 (can get all items and anoints) with Lootsplosion - extra loot is justified by saying it is due to a higher difficulty and Holy Crit - there is a bigger chance to deal less damage if you don’t shoot accurately or don’t aim at the right body part / location for the given enemy, so increased difficulty for not playing well.
The above two seems to be the best combo, any other choice completely changes the game flow and the feel of the game being Borderlands.
I really wish the new mode will be a max level most difficult setting without any crazy ■■■■ like bobble heads or ugly lava patches all of a sudden with no lore (I know BL games are crazy to start with, but still stuff needs to make sense in universe).