Which is the better annoint?

Call me a noob but which is better? 125% boss damage ASE OR 100% ASE . The 100% will work on all enemies won’t it? Making it the better choice in general? Or am i wrong

It depends on how your playing your end game.
If your end game activities are slaughter shaft and trials. I would say yes 100% is the better option.
If the end game for you is farming bosses and running raids than I would say the 125% on bosses and named enemies is the better option.

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In general play, I would say the 100% one.

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Yeah I’d put more weight on the 100% ASE if I have to choose only one.

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