It would be quiet sad if I had to buy a US-version to play with american friends 
Well, since I´m on XBox I guess we consoleros can play with anyone on PS/XBox-live, but for PC-gamers it would be cool to choose a region before matchmaking.
Well, it would be rather cool for all of us to choose a region upfront when starting multiplayer sessions!
Think of it, when I´m awake at 4pm in the night I could just click for “US” and play with friends who are still up^^
Also it would be rather nice for people with laggy internet connection. Sometimes (at ME3-multiplayer) lags get unbearable for either me or my teammembers if we live to far apart.
But, even if I have no knowledge about progamming and stuff, I´m sure its not realizable on all platforms, maybe not even on one of them… would be cool though^^